Clinical study
Test clinical hypotheses with in vivo models for informed decisions
By combining trials in both standardized TADhuMouse® and the TADmaps® mathematical models, you can make decisions based on extrapolable data (not trial and error), strengthen regulatory and ethical arguments, and reduce clinical trial costs, reducing the number of patients needed.
NARROWING FIRST-IN-HUMAN DOSING RANGES
PRE-VALIDATING DRUG COMBINATIONS
ANTICIPATING RESISTANCE MECHANISMS IN INFECTIOUS DISEASES
AD-HOC ASSAYS TO TEST DIFFERENT HYPOTHESIS
Do you have a compound in this phase?
Which TAD services can help you to move forward?
De-risk your clinical studies for regulatory filings
Make the TADhuMouse® your experimental tool of choice for de-risking studies. The TADhuMouse® is a fully validated, time-tested in your project and robust in vivo system endowed with complete PK/PD information on the treatment you work with.
Adapt your relevant drug-sensitive and –resistant field strains of P. falciparum
Create your own TADhuMouse® model(s) to test de-risking your trial hypothese.
PK/PD evaluation in your clinically relevant TADHuMouse® models
Test experimentally how the field isolates you deal with affect the PK/PD and Total Effective Dose.
Irresistible Test
Measure the effect of clinically relevant mutations on the susceptibility in vivo of P. falciparum clinical isolates.
Combination strategy validation
Test your treatment hypothesis in your own TADhuMouse® tools for clinical strains in vivo.
Post-marketing efficacy/safety checks
Test your trial designs in field isolates before committing to full clinical studies.
